Potential contribution of amorphous calcium carbonate (ACC) in relieving inflammatory symptoms
Inflammation is an action of the immune system against injuries, stimuli, or contaminants such as viruses, bacteria, or fungi that have invaded the human body. There are two types of inflammation: acute inflammation and chronic inflammation. Acute inflammation is necessary and short-lived. Chronic inflammation is a condition in which the body cannot completely overcome the inflammatory factors. Chronic inflammation continues to exist for a long time on "low fire", and its existence becomes a burden on the body.
Autoimmune disease is a misconception of the immune system against healthy cells and tissues even though there is no presence of a foreign factor such as a bacterium or virus. This self-attack (of the immune system on the body) occurs through the production of autoantibodies and cytokines (inflammatory proteins). As a result, inflammation is caused to cells, tissues, and organs are destroyed.
In many cases where the immune system is weakened and its ability to create the inflammation is avoided, the danger to the body will even be greater than the inflammation. It should be remembered that inflammation is a natural action of the immune system, and it is part of its biological and complex response to harmful stimuli.
What immune purpose is inflammation for?
In our body there are immunological (immune) cells that are used as "sensors", and their purpose is to find out if there is any damage to the tissue, and to detect unwanted bacteria, viruses and fungi. When these negative elements are present in the body, these and other immunological cells localize on the infected area or foreign cells and attack them. It can also be caused by physical injury and cancer. In general, the body uses inflammation to eliminate the primary cause of cell damage and / or clear dead cells that have been damaged because of the problem and its outcome (inflammation). It is worth noting that people suffering from autoimmune diseases, tend to suffer from chronic infections because their immune system recognizes healthy organs and body cells as foreign elements, and attacks them.
What is the mechanism of action of inflammation?
When the body signals an injury, white blood cells, and various antibodies localize on the affected area or cells and attack it - causing the development of inflammation. During this process, cells of the immune system release substances called "inflammatory mediators" (which include hormones that stimulate the nerves and cause the transmission of pain signals to the brain). As a result, the small blood vessels in the tissue dilate and allow more blood to reach the damaged tissue (therefore "inflamed" areas become redder and warmer). The increased blood flow allows more immune cells to reach the damaged tissue to aid in the healing process.
Types of infections: acute inflammation and chronic inflammation.
There are two types of inflammation: acute inflammation and chronic inflammation. Acute inflammation is the body's initial response to harmful stimuli and is an initiative of the body to heal itself. This type of inflammation usually lasts up to two-four weeks, its symptoms appear quickly and in the end, the body returns to the state it was in before the injury or illness.
Unlike acute inflammation, chronic inflammation lasts a long time and tends to recur even after periods of remission when it comes to autoimmune diseases. Many of the chronic infections are autoimmune. Known chronic infections are rheumatoid arthritis, psoriasis (skin disease), multiple sclerosis, and inflammatory bowel diseases like Crohn's disease or colitis.
Signs (symptoms) of acute inflammation:
Swelling and internal pain and an inflatable wound, which turns red and is accompanied by pain are clear signs of inflammation. There are five symptoms there may be signs of acute, external, or internal inflammation:
- Loss of function (inability to move a diseased joint properly, inability to smell during a cold, or difficulty breathing)
Inflammation does not always cause all five symptoms. There are infections that occur "quietly" with no symptoms at all.
How can amorphous calcium carbonate (ACC) help suppress and cure inflammation?
Amorphical has been researching in recent years the effect of amorphous calcium carbonate (ACC) in the suppression and healing of various infections, including autoimmune diseases such as multiple sclerosis and Crohn's disease. Pre-clinical trials, conducted and currently conducted in the company's laboratories, indicate anti-inflammatory and anti-cancer medical activities. These trials support personal reports of improvement and recovery of cancer patients and athletes with inflammation, who have used high doses of ACC. The company is currently examining these issues at the clinical trials (trials in patients).
Amorphous calcium carbonate (ACC) has been found to help lower the activity of cathepsin B and cathepsin K enzymes, whose high levels are linked to chronic infections such as rheumatoid arthritis in the case of cathepsin K inflammation, and the formation of cancer metastases in the case of cathepsin B.
The scientific explanation for these promising observations relates to locally developing acidity in an area where there is inflammation or cancerous growth. This acidity increases destructive activities such as over-excretion of healthy cells with the help of catechins or inhibition of the immunological system. The desired acidity range in the blood system and other body fluids (excluding gastric juices) is between 7.35 and 7.45 on the pH scale. When the pH level drops below 7.35, the infected blood or organ is in a state of "acidosis". This condition is undesirable, increases the damage to the body accompanied by pain and at the same time, the body's self-healing abilities decrease. When the pH level in the blood falls below 6.8 (more acidic) - the patient is in danger of death. In infected organs, the level of acidity can be even higher and harmful, even when it is not life-threatening. The ACC helps by neutralizing the unwanted acidity in the infected blood or organ.
The properties of the ACC (amorphous calcium carbonate) that differentiate it from regular calcium carbonate (of which most calcium supplements are composed).
The ACC is endowed with several properties that do not exist in crystalline calcium carbonate (which constitutes about 4% of the Earth's crust, including substances known as marble and limestone) and in other calcium supplements:
- Nanometric particles: These particles are up to a million times smaller than lime grains and can be absorbed into the body as ACC particles, without the need to dissolve and break them down first into calcium ions.
- Reducing the level of acidity: When the nanometer particles are transferred to the body fluids, they still contain the carbonate ions (which are usually broken down in the stomach into carbon dioxide). These ions are basic in nature and bind rapidly to hydrogen ions. The acids formed in acidosis conditions. The result is that both the level of acidity decreases and ions of bicarbonate is formed - which is the natural and main molecule in our body for regulating the level of acidity.
- Solubility level 120-100 times higher than the crystalline equivalent material: This is a unique feature of the ACC. It is worth noting that these are the acidity domains, which are formed by acidosis. Thanks to this high level of solubility, the ACC can neutralize the unwanted local acidity in the infected blood or organ. The result is that many disease activities, in which the acid is formed, decrease.
Studies currently being conducted at Amorphical in a variety of biomedical fields indicate that amorphous calcium carbonate (ACC) has benefits as well as a superior activity over that of sodium bicarbonate, which is the currently accepted product for neutralizing acidity in extreme conditions and in sports. Amorphical has been conducting pre-clinical and now also clinical trials on the subject of treating advanced cancer patients in advanced stages.
In addition to disease, strenuous exercise also lowers muscle pH. This slows down the metabolic activity of the muscles and therefore the energetic abilities of the muscle fade. Experiments done with athletes show the link between lowering acidity and improving performance and faster recovery.
To improve ACC absorption and prevent its partial breakdown in the stomach, Amorphical has developed the DENSITYSPORT product that comes in powder form. DENSITYSPORT is optimally absorbed into the bloodstream through the oral mucosa. It is recommended to hold for a few minutes under the tongue to maximize the level of absorption in the bloodstream.
Density, the Amorphous Calcium is a calcium supplement that is absorbed 2 to 4.6 times higher than crystalline calcium carbonate (For the experiment that shows the better absorption of the amorphous calcium, click here). Density helps more and more people around the world to improve their quality of life by increasing bone mass or slowing down its rate.